Just a quick heads-up: With the latest snapshot, IOTA also changed its underlying crypto algorithms, which requires a complete refactoring of the API libraries.
Unfortunately, the current versions of PyOTA are not compatible with the new crypto algorithms. If you are using PyOTA v1.1.3 or v1.2.0-beta, please immediately stop using it for applications connected to mainnet until v1.2.0 final is released!
I'm working with the core devs to get this resolved ASAP!
More info about what else is coming in v1.2.0: